Long-Term Outcomes of Biologic Therapy in Ulcerative Colitis

Abstract

Biologic therapies have transformed ulcerative colitis treatment, but long-term real-world data remain limited. This cohort study evaluated clinical outcomes in patients receiving biologic agents over a ten-year period. Sustained clinical remission was achieved in a majority of patients, although loss of response occurred in a subset. Safety profiles were acceptable, with infections being the most common adverse events. These findings provide valuable evidence for long-term biologic therapy use.